Small amounts of HMB are present in many foods of animal and plant origin, especially alfalfa and catfish. The amino acid leucine is metabolized into a compound
called alpha-ketoisocaproate (KIC), which is then turned into HMB by the body. Dietary
supplements of HMB are also available.
HMB has been used in
connection with the following conditions (refer to the individual
health concern for complete information):
Reliable
and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies
suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal
or no scientific evidence. For a supplement, little scientific support and/or minimal health
benefit.
Who is likely to be deficient?
HMB is not an essential nutrient. The body creates HMB from leucine, so any diet containing
sufficient amounts of leucine (most do) should lead to the adequate production of HMB. Limited
evidence indicates that athletes may benefit from supplemental intake of HMB.
How much is usually taken?
Most people do not need to use HMB. For those involved in regular exercise who do choose to
take this supplement, the research generally uses 3 grams of HMB per day in combination with
resistive exercise, such as weight lifting.
Are there any side effects or interactions?
No safety issues have been reported in the limited number of studies currently
available.
At the time of writing, there were no well-known drug interactions
with HMB.
The information presented in Aisle7 is for informational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience,
or traditional usage as cited in each article. The results reported may not necessarily occur
in all individuals. For many of the conditions discussed, treatment with prescription or over
the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist
for any health problem and before using any supplements or before making any changes in
prescribed medications. Information expires February 2010.
For an herb, supported by traditional use but minimal
or no scientific evidence. For a supplement, little scientific support and/or minimal health
benefit.