Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
May Be Beneficial:Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them.
Zinc*
May Be Beneficial:Side effect
reduction/prevention—Taking these supplements may help reduce the likelihood and/or
severity of a potential side effect caused by the medication.
Iron
Avoid:Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results.
High-potassium foods*
Potassium supplements*
Salt substitutes*
Check:Other—Before taking any of these supplements or eating any of
these foods with your medication, read this article in full for details.
Sodium
Supportive interaction
None known
Reduced drug
absorption/bioavailability
None known
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Dietary Supplements
Potassium
An uncommon yet potentially serious side effect of taking ACE inhibitors is increased blood
potassium levels.123 This problem is more likely to occur
in people with advanced kidney disease. Taking potassium supplements,4
potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and
others),567 or large amounts of high-potassium foods at the
same time as ACE inhibitors could cause life-threatening problems.8 Therefore,
people should consult their healthcare practitioner before supplementing additional potassium
and should have their blood levels of potassium checked periodically while taking ACE
inhibitors.
Sodium
In a short-term study of nine overweight men, enalapril plus a low-salt diet reduced blood
pressure more than a low-salt diet
alone.9 Additionally, enalapril plus a low-salt diet resulted in better insulin response than the low-salt diet alone. The
importance of this preliminary information for
overweight people with high blood pressure
is unclear.
Iron
In a double-blind study of patients who had developed a cough attributed to an ACE inhibitor,
supplementation with iron (in the form of 256 mg of ferrous sulfate per day) for four weeks
reduced the severity of the cough by a statistically significant 45%, compared with a
nonsignificant 8% improvement in the placebo group.10
Zinc
In a study of 34 people with hypertension, six months of captopril or enalapril treatment led
to decreased zinc levels in certain white blood cells.11
It makes sense for people taking enalapril long term to consider, as a precaution, taking a
zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain
no more than 99 mg of potassium, probably not enough to trigger the above-mentioned
interaction.) Supplements containing zinc should also contain copper, to protect against a
zinc-induced copper deficiency.
Interactions with Foods and Other Compounds
Food
Enalapril may be taken with or without food.12
References (To view, roll mouse over the "References" heading; to hide, click on the heading)
1. Good CB, McDermott L, McCloskey B. Diet and serum potassium in
patients on ACE inhibitors. JAMA 1995;274:538.
2. Rush JE, Merrill DD. The Safety and tolerability of lisinopril in
clinical trials. J Cardiovasc Pharmacol 1987;9(Suppl 3):S99–107.
3. Sifton DW, ed. Physicians’ Desk Reference. Montvale,
NJ: Medical Economics Company, Inc., 2000, 1965–8.
4. Burnakis TG, Mioduch HJ. Combined therapy with captopril and potassium
supplementation. A potential for hyperkalemia. Arch Intern Med
1984;144:2371–2.
6. Ray K, Dorman S, Watson R. Severe hyperkalemia due to the concomitant
use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening
interaction. J Hum Hypertens 1999;13:717–20.
7. Sifton DW, ed. Physicians’ Desk Reference. Montvale,
NJ: Medical Economics Company, Inc., 2000, 1965–8.
8. Stoltz ML. Severe hyperkalemia during very-low-calorie diets and
angiotensin converting enzyme use. JAMA 1990;264:2737–8 [letter].
9. Egan BM, Stepniakowski K. Effects of enalapril on the hyperinsulinemic
response to severe salt restriction in obese young men with mild systemic hypertension. Am
J Cardiol 1993;72:53–7.
10. Lee SC, Park SW, Kim DK, et al. Iron supplementation inhibits cough
associated with ACE inhibitors. Hypertension 2001;38:166–70.
11. Golik A, Zaidenstein R, Dishi V, et al. Effects of captopril and
enalapril on zinc metabolism in hypertensive patients. J Am Coll Nutr
1998;17:75–8.
12. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihypertensives,
Angiotensin Converting Enzyme Inhibitors. In Facts and Comparisons Drug Information.
St. Louis, MO: Facts and Comparisons, Apr 1998, 165o–5p.
The information presented in Aisle7 is for informational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience,
or traditional usage as cited in each article. The results reported may not necessarily occur
in all individuals. For many of the conditions discussed, treatment with prescription or over
the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist
for any health problem and before using any supplements or before making any changes in
prescribed medications. Information expires February 2010.
