Hydralazine is a drug used to lower blood pressure in people with hypertension. Hydralazine relaxes the muscles that
control the diameter of blood vessels. This relaxation allows the blood vessels to dilate
(open wider), lowering blood pressure.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
May Be Beneficial:Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them.
Vitamin B6
Side effect reduction/prevention
None known
Supportive interaction
None known
Reduced drug
absorption/bioavailability
None known
Adverse interaction
None known
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Dietary Supplements
Vitamin
B6
Vitamin B6 can bind to hydralazine to form a complex that is excreted in the urine, increasing
vitamin B6 loss.1 This may lead to vitamin B6 deficiency.2 People taking
hydralazine should consult with their doctor to discuss the possibility of vitamin B6
supplementation.
Interactions with Foods and Other Compounds
Food
Taking hydralazine with food improves the absorption of the drug.3 People with
questions should ask their prescribing doctor or pharmacist.
Alcohol
Alcohol causes blood vessels to dilate, lowering blood pressure. This action may add to the
blood pressure-lowering effect of hydralazine and increase the risk of dizziness, fainting, or
accidental falls. People taking hydralazine should avoid alcohol and should read all product
labels carefully for alcohol content.
References (To view, roll mouse over the "References" heading; to hide, click on the heading)
2. Raskin NH, Rishman RA. Pyridoxine-deficiency neuropathy due to
hydralazine. N Engl J Med 1965;273:1182–5.
3. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihypertensives,
Vasodilators, Hydralazine. In Facts and Comparisons Drug Information. St. Louis, MO:
Facts and Comparisons, Dec 1993, 163r–4b.
The information presented in Aisle7 is for informational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience,
or traditional usage as cited in each article. The results reported may not necessarily occur
in all individuals. For many of the conditions discussed, treatment with prescription or over
the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist
for any health problem and before using any supplements or before making any changes in
prescribed medications. Information expires February 2010.
