Chlorpheniramine is an antihistamine used to relieve allergic rhinitis (seasonal allergy) symptoms
including sneezing, runny nose, itching, and watery eyes. It is also used to treat immediate
allergic reactions. Chlorpheniramine is available in nonprescription products alone and in
combination with other nonprescription drugs, to treat symptoms of allergy, colds, and upper respiratory infections.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
Avoid:Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results.
Henbane*
Depletion or interference
None known
Side effect reduction/prevention
None known
Supportive interaction
None known
Reduced drug
absorption/bioavailability
None known
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Herbs
Henbane (Hyoscyamus niger)
Antihistamines, including chlorpheniramine, can cause “anticholinergic” side
effects such as dryness of mouth and heart palpitations. Henbane also has anticholinergic
activity and side effects. Therefore, use of henbane with chlorpheniramine could increase the
risk of anticholinergic side effects,1 though apparently no interactions have yet
been reported. Henbane should not be taken except by prescription from a physician trained in
its use, as it is extremely toxic.
Interactions with Foods and Other Compounds
Alcohol
Chlorpheniramine causes drowsiness.2 Alcohol may intensify this effect and increase
the risk of accidental injury.3 To prevent problems, people taking chlorpheniramine
or chlorpheniramine-containing products should avoid alcohol.
References (To view, roll mouse over the "References" heading; to hide, click on the heading)
1. Blumenthal M, ed. The Complete German Commission E
Monographs. Austin, TX: American Botanical Council, 1998, 146.
2. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and
Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998, 192.
3. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and
Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998, 192.
The information presented in Healthnotes is for informational purposes
only. It is based on scientific studies (human, animal, or in vitro), clinical
experience, or traditional usage as cited in each article. The results reported may not
necessarily occur in all individuals. For many of the conditions discussed, treatment with
prescription or over the counter medication is also available. Consult your doctor,
practitioner, and/or pharmacist for any health problem and before using any supplements or
before making any changes in prescribed medications. Information expires June 2009.
